The series is set at Skinwalker Ranch, a 500-acre ranch that is the site of purported paranormal and UFO-related activities, and follows a team of investigators and sceptics investigating the reports. Team members include Brandon Fugal, the ranch's owner, and aerospace engineer Travis S. Taylor. The show features the team utilising technologies such as ground-penetrating radar to investigate anomalies such as ionizing radiation, dire wolves, UFOs, a human bone discovered in an airtight cellar, and cattle mutilation.