World's Most Unexplained features some of the greatest and most impactful mysteries of history. Exploring events that defy rational and scientific explanations, such as flight 191, a notorious LA hotel and more. For centuries, believers and skeptics have debated the phenomenon of stigmata — the mysterious wounds of Christ appearing on human bodies. World's Most Unexplained unravels the incredible story of Padre Pio and asks: miracle, mind over matter, or a carefully crafted hoax?